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Nonetheless, current evidence supports melatonins use for improving sleep and circadian alignment in aging, which itself can confer systemic benefits (better sleep can improve memory consolidation, metabolic regulation, and mood, indirectly supporting healthier aging) (Moslehi et al., 2022

Published studies in non-diabetics demonstrated that patients on liraglutide lost an average of 8% body weight

Malondialdehyde (MDA) is a byproduct of lipid peroxidation and serves as an important marker for oxidative stress in cells and tissues ( Figure 3A )

To advance our understanding, it is essential that future research integrates biochemical characterization of each variants impact on enzyme function with in vivo modeling of physiological outcomes